Iranian Journal of Psychiatry 2017. 12(3):201-205.

Relationship between BMI and depression, according to the rs16139NPY gene
Hamideh Pishva, Atieh Dolatian, Seyed Masoud Arzaghi, Mostafa Qorbani


Objective: obesity and depression are likely to interact mutually which makes it unclear if obesity causes depression or it leads to obesity; and how the genotypes have a role in obesity and depression.

Methods and Materials: This cross sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive Iranian Multicenter Osteoporosis Study (IMOS). Anthropometric measurements and depression were assessed. To investigate the NPY polymorphism, PCR-RFLP was used. Binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphism

Results: the frequency of NPY rs16139 was 6%. No significant association could be found between NPY genotypes and depression (p >0.05). Furthermore, the results suggest that those with central obesity seem an increased chance of developing depression (P=0.02).

Conclusion: There is a significant relationship between obesity and depression and obesity is a possible cause of depression. Waist circumference and abdominal obesity as components of metabolic syndrome have the most important effects on depression.


Depression, NPY polymorphism, , Obesity

Full Text:



Feizi I, Naghizadeh Baghi A, Rahimi A, Nemati S. The Relationship between Body Mass Index and Depression in Female Students of Ardabil University of Medical Sciences. J Ardabil Univ Med Sci. 2012; 12(2):213-221. (Full Text in Persain).

de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res [Internet]. Elsevier Ltd; 2010 Jul 30 [cited 2014 Feb 13];178(2):230–5. Available from:

Werrij MQ, Mulkens S, Hospers HJ, Jansen A. Overweight and obesity: the significance of a depressed mood. Patient Educ Couns [Internet]. 2006 Jul [cited 2014 Feb 2];62(1):126–31. Available from:

Morales-Medina JC, Dumont Y, Quirion R. A possible role of neuropeptide Y in depression and stress. Brain Res [Internet]. Elsevier B.V.; 2010 Feb 16 [cited 2014 Feb 26];1314:194–205. Available from:

Wang Y, Yang Y, Hui L, Tie C, Li F, Xu Z-QD, et al. A neuropeptide Y variant (rs16139) associated with major depressive disorder in replicate samples from Chinese Han population. PLoS One [Internet]. 2013 Jan [cited 2014 Feb 26];8(2):e57042. Available from:

Khalilitehrani A, Qorbani M, Hosseini S, Pishva H. The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults. Gene [Internet]. Elsevier B.V.; 2015;563(2):125–9. Available from:

Masoudi-Kazemabad A, Jamialahmadi K, Moohebati M, Mojarrad M, Dehghan-Manshadi R, Forghanifard MM, et al. High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease. Gene [Internet]. Elsevier B.V.; 2012 Mar 15 [cited 2014 Feb 26];496(1):22–7. Available from:

Pharmacology C, Unit ED, Amsterdam VU, Karvonen MK, Pesonen U, Koulu M, et al. Association of a leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat Med. Nature Publishing Group; 1998;4(12):1434–7.

Ding B. Distribution of the NPY 1128C allele frequency in different populations. 2003;1199–204.

Zhao G, Ford ES, Li C, Tsai J, Dhingra S, Balluz LS. Waist circumference, abdominal obesity, and depression among overweight and obese U.S. adults: National Health and Nutrition Examination Survey 2005-2006. BMC Psychiatry [Internet]. BioMed Central Ltd; 2011 Jan [cited 2014 Oct 30];11(1):130. Available from:

Akbaraly TN, Kivimäki M, Brunner EJ, Chandola T, Marmot MG, Singh-Manoux A, et al. Association between metabolic syndrome and depressive symptoms in middle-aged adults: results from the Whitehall II study. Diabetes Care [Internet]. 2009 Mar [cited 2014 Dec 8];32(3):499–504. Available from:

Dunbar J a, Reddy P, Davis-Lameloise N, Philpot B, Laatikainen T, Kilkkinen A, et al. Depression: an important comorbidity with metabolic syndrome in a general population. Diabetes Care [Internet]. 2008 Dec [cited 2014 Dec 8];31(12):2368–73. Available from:

Takeuchi T, Nakao M, Nomura K, Yano E. Association of metabolic syndrome with depression and anxiety in Japanese men. Diabetes Metab [Internet]. 2009 Feb [cited 2014 Nov 28];35(1):32–6. Available from:

Sjöholm LK, Melas P a, Forsell Y, Lavebratt C. PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. J Affect Disord [Internet]. Elsevier B.V.; 2009 Nov [cited 2014 Dec 8];118(1-3):124–30. Available from:

Domschke K, Dannlowski U, Hohoff C, Ohrmann P, Bauer J, Kugel H, et al. Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression. Eur Neuropsychopharmacol [Internet]. Elsevier B.V. and ECNP; 2010 May [cited 2014 Feb 26];20(5):301–9. Available from:

Kakko T, Jaakkola U, Raitakari OT, Kallio J. Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Diab Vasc Dis Res [Internet]. 2011 Jul [cited 2014 Dec 9];8(3):221–8. Available from:

Ukkola O, Kesäniemi Y a. Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects. Eur J Clin Nutr [Internet]. 2007 Sep [cited 2014 Dec 9];61(9):1102–5. Available from:

van Rossum CTM, Pijl H, Adan R a H, Hoebee B, Seidell JC. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. Int J Obes (Lond) [Internet]. 2006 Oct [cited 2014 Dec 9];30(10):1522–8. Available from:

Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin- signaling pathway with obesity in Brazil. 2002;1179–85.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.