Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 13 3 2018 06 14 175 183 EN Fatemeh Ghandi Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Amir Sadeghi Basic and Molecular Epidemiology of Gastroenterological Disorder Research Center, Research Institute for Gastroenterology and Liver Diseases ,Shahid Beheshti University of Medical Sciences, Tehran, Iran. Maryam Bakhtyari Department of Clinical Psychology, Shahid Beheshi University of Medical Sciences, Tehran, Iran. saeed imani Department of Clinical and Health Psychology, Shahid Beheshti University, Tehran, Iran. Saeed Abdi Basic and Molecular Epidemiology of Gastroenterological Disorder Research Center, Research Institute for Gastroenterology and Liver Diseases ,Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyed Shahab Banihashem Department of Psychiatry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2017 07 16 Objective: Irritable bowel syndrome is a common gastrointestinal disorder. The perception of stress and GI-specific anxiety play a key role in irritable bowel syndrome (IBS). The present study aims at comparing the efficacy of mindfulness-based stress reduction therapy with emotion regulation on the quality of life and severity in patients IBS. Method: This randomized clinical trial was conducted in 3 phases: pretest, posttest, and follow-up. Follow-up was performed 2 months after the last intervention. The study population consisted of 24 IBS patients who were randomly selected according to Rome-IV Criteria and were then divided into 3 eight-member groups: (1) mindfulness-based stress reduction, (2) emotion regulation, and (3) control group. IBS-QOL34 and IBS-SSS were administered as assessment tools to all the 3 groups. The experimental groups were subjected to MBSR and ER psychotherapy, while the control group received no psychological intervention. After the 2-month follow-up, the 3 groups were evaluated again. Results: The results revealed that MBSR improved the quality of life of IBS patients and dicreased severity of their condition. The findings of between and within subjects design revealed that the difference between MBSR and control groups was significant in IBS at follow-up (p = 0.01). Conclusion: MBSR could be considered as a new, effective, and stable method in psychotherapy, in irritable bowel syndrome. https://ijps.tums.ac.ir/index.php/ijps/article/view/1141 https://ijps.tums.ac.ir/index.php/ijps/article/download/1141/735