Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 9 1 2014 03 15 37 41 Sara Bensaeed Azad University, Tehran, Iran Atefeh Ghanbari Jolfaei Department of psychiatry Iran university of medical sciences, Minimally Invasive surgery Research Center, Tehran, Iran Farhad Jomehri Department of psychology, Allameh Tabatabaii University, Tehran, Iran Alireza Moradi Department of psychology Tarbiyat Moalem University, Tehran, Iran 2015 10 14 Objective: The aim of this study was to compare the clinical temperaments and characters of Iranian patients with Major Depressive Disorder (MDD) with healthy controls Method: The study participants included 47 outpatients with Major Depressive Disorder (MDD) and 120 normal controls with no psychiatric disorders. Sampling method was convenience. The MDD patients were diagnosed as MDD by a psychiatrist using the Persian structured clinical interview for axis I disorders (SCID-I), and they completed at least 8 weeks of antidepressant treatment. All the patients filled out the Persian version of the Temperament and Character Inventory (TCI). Data were analyzed using SPSS version 17, Chi square, T test and Multiple Regression. The level of significance was set at 5%. Results: The present study demonstrates a link between depression and lower persistence (p≤0.001), self-directedness (p≤0.001) and cooperativeness (p≤0.001) scores. A negative correlation between age and Harm Avoidance (p≤0.001) was observed in both groups . Conclusion: Lower scores of persistence (P), self-directedness (SD) and cooperativeness (CO) were observed in patients with depression more than controls even in the remission phase which could indicate a relationship between these traits and depression. https://ijps.tums.ac.ir/index.php/ijps/article/view/128 https://ijps.tums.ac.ir/index.php/ijps/article/download/128/124