Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 15 2 2020 03 27 159 168 Davoud Adham Department of Public Health, School of Health, Ardabil University of Medical Sciences, Ardabil, Iran Malek Abazari Department of Public Health, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran. 2019 12 19 Objective: Physical activity (PA), insomnia, depression, and worry were the key factors affecting pregnant women’s quality of life (QoL). The present study aimed to determine quality of life and its relationship with physical activity, insomnia, depression, and worry in pregnant women. Method: This was an observational cross sectional study, conducted among 256 healthy pregnant women using 5 questionnaires: WHOQOL-brief (WHO Quality of Life Questionnaire, brief version, ISI (Insomnia Severity Index), PSWQ (Penn State Worry Questionnaire), ZSRDS (Zung Self-Rating depression Scale), and Pregnancy Physical Activity Questionnaire (PPAQ). Results: There was a significant relationship between general QoL, insomnia, and worry with educational background, number of children, and occupation (P < 0.05). Depression had a significant relationship with occupation (P < 0.05). PA did not have a significant relationship with demographic information. However, insomnia had a significantly negative relationship with general QoL, general health, and psychological health (P < 0.05). The worry variable had also a significant negative relationship with general QoL, general health, and physiological health (P < 0.05). Depression had a significant negative relationship with general health, physical health, and psychological health (P < 0.05). There was no significant relationship between physical activities in pregnancy with QoL, depression, worry, and insomnia. Conclusion: Women need to be informed about the necessity of controlling and reducing insomnia, worry, and depression to have a higher QoL. PA declined during the second and third trimester of pregnancy. However, PA in pregnancy can positively impact general QoL. https://ijps.tums.ac.ir/index.php/ijps/article/view/1989 https://ijps.tums.ac.ir/index.php/ijps/article/download/1989/914