Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 7 2 2012 06 15 97 103 Alireza Khoshnevisan Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Narges Sistany Allahabadi 2015 10 14 Localization of brain lesions and prevention of damage to vital structures are important in operation of brain pathologies. Despite development of many techniques including angiography, MRI, sonography, and frame base stereotaxy, a more accurate localizing technique is still needed (1, 2). A step forward to achieve this goal is to develop a navigation system. In this manuscript, we explained some clinical applications, advantages, and disadvantages of navigation system and tried to have a short glimpse on its future. https://ijps.tums.ac.ir/index.php/ijps/article/view/203 https://ijps.tums.ac.ir/index.php/ijps/article/download/203/199