Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 17 4 2022 09 14 455 461 Fatima Muhammad Ibrahim Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. Maryam Mohammad Ibrahim Reproductive Health Department, School of Nursing and Midwifery, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran. Haniyeh Abbassinya Department of Midwifery, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. Faezeh Rostami Cheri Department of Nursing and Midwifery, Islamic Azad University of Arak, Arak, Iran. Samaneh Nazarpoy Shirehjini Department of Clinical Psychology, Faculty of Psychology, Khomeyni Shahr Branch, Islamic Azad University, Isfahan, Iran. Farnoosh Farahbod Obstetric & Gynecologist Specialist, Isfahan University of Medical Sciences, Isfahan, Iran. Nasim Khademi Department of Midwifery, Nursing and Midwifery Sciences Development Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran. 2022 07 26 2022 08 22 Objective: Sleep disturbance is one of the most prevalent problems in post-menopausal females. The current research intended to evaluate the effects of Dracocephalum on sleep disorder in post-menopausal females. Method: The current study is a randomized, double-blind controlled trial, in which 110 post-menopausal women were randomly allocated to Dracocephalum or placebo groups. The intervention group took Dracocephalum capsules containing 250 mg Dracocephalum extract twice daily for one month. While, the placebo group took the same capsule containing 250 mg of starch twice daily for one month. Pittsburgh Sleep Quality Index was completed by the participants of both groups before and after the treatment and the data obtained were analyzed with Chi-square, paired and independent t-test in SPSS (version 20). Results: The mean score of sleep quality before and after the treatment was 12.69 ± 3.98 and 8.58 ± 1.97 in the treatment group, respectively. Also, the score of sleep quality in the placebo group was 13.48 ± 2.60 and 11.21 ± 2.74 at the beginning and end of the research, respectively. The symptoms of sleep disorder in the intervention group significantly improved after the treatment (P < 0.001), while this was not the case with the placebo group (P = 0.155). Besides, there was a significant difference between the two groups in the mean score of sleep quality after the treatment (P = 0.012). Conclusion: Dracocephalum extracts are effective in reducing symptoms of sleep disorders in post-menopausal women.   https://ijps.tums.ac.ir/index.php/ijps/article/view/3340 https://ijps.tums.ac.ir/index.php/ijps/article/download/3340/1088