Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 9 3 2014 09 15 184 7 Babak Roshanaei-Moghaddam Tehran University of Medical Sciences, Tehran Iran, Iranian National Center for Addiction Studies (INCAS), Tehran, Iran Michael C Pauly University of Washington Department of Psychiatry and Behavioral Sciences. United States 2015 10 14 Objevtive: This comment article reviews the literature to explore whether the use of ECT for the treatment of methamphetamine dependence can be justified by scientific rationale and/or evidence. Method: This article reviews the literature on the use of ECT in addictive disorders. It describes a patient with methamphetamine dependence treated with ECT. It then offers a historical review of the moral and ethical difficulties encountered in the treatment of addictive disorders. It proposes a dynamic understanding as to why clinicians might deploy such brutal actions in the face of hopeless and emotionally intense encounters. Results: We found no scientific evidence or justification for ECT as a treatment of methamphetamine dependence or as the first line treatment for methamphetamine-induced psychiatric comorbidities Conclusion: the current available evidence does not support using ECT for the treatment of addictive disorders, and hence is unethical, unacceptable and inhumane and warrants immediate social and po itical attention. https://ijps.tums.ac.ir/index.php/ijps/article/view/37 https://ijps.tums.ac.ir/index.php/ijps/article/download/37/33