Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 1 1 2006 03 15 19 26 Hossein Kaviani Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 17 Objective:This study aimed to examine the effects of haloperidol and amphetamine on human startle response modulated by emotionally-toned film clips. Method: Sixty participants, in two groups (one receiving haloperidol and the other receiving amphetamine) were tested using electromyography (EMG) to measure eye-blink muscle (orbicular oculi) while different emotions were induced by six 2-minute film clips. Results: An affective rating shows the negative and positive effects of the two drugs on emotional reactivity, neither amphetamine nor haloperidol had any impact on the modulation of the startle response. Conclusion: The methodological and theoretical aspects of the study and findings will be discussed. https://ijps.tums.ac.ir/index.php/ijps/article/view/398 https://ijps.tums.ac.ir/index.php/ijps/article/download/398/393