Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 20 4 2025 09 14 427 428 Gonzalo Quintana Departamento de Psicología, Facultad de Ciencias Sociales, Universidad de Chile. Jaime Barrientos Facultad de Psicología, Universidad Alberto Hurtado. 2025 08 12 2025 09 06 Daftari and Khaleghi’s recent editorial misrepresents peer-reviewed evidence on sex, gender, and sexual orientation, pathologizing diversity via selective citation and conceptual conflation. Contrary to their claims, empirical research demonstrates that while biological sex is largely chromosomal, gender, identity, and orientation are multidimensional and non-pathological. Their evolutionary and neurobiological arguments lack validity, ignoring cross-species evidence of same-sex behavior and misinterpreting descriptive neuroanatomical findings as “anomalies.” Psychiatric consensus rejects homosexuality as a disorder, attributing mental health disparities among sexual minorities to stigma, not intrinsic pathology. We call for editorial accountability and reaffirm that gender and sexual diversity are natural human variations grounded in robust scientific evidence. https://ijps.tums.ac.ir/index.php/ijps/article/view/4351