Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 0 0 2026 08 01 1 15 Maliheh Abbasi Department of Nursing, Bandar Gaz Branch, Islamic Azad University, Bandar-e-Gaz, Iran. Mojtaba Darvishi Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Aida Abazari Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran. Zaker Saeedinejad Department of Internal Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. Seyedeh Paria Saeedi Students' Scientific Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Sayed Hassan Faghihi Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Amin Haghgoo Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. 2025 10 17 2026 06 22 Objective: Acute respiratory infection (ARI) represent one of the foremost contributors to worldwide mortality. Psychological factors, notably anxiety, commonly obstruct patient recovery. Conventional medical approaches rarely account for the interplay between these psychological and physiological factors. This study aimed to determine the effects of EMDR on hemodynamic indices, anxiety levels, and sleep quality in hospitalized patients with ARI. Method: In 2022, a six-month parallel-group randomized controlled trial was conducted in Yasouj, Iran, including 89 hospitalized patients with ARI. Participants were randomly assigned to either an intervention group receiving three bedside Eye Movement Desensitization and Reprocessing (EMDR) sessions (45–90 minutes each) or a control group receiving standard care. Outcomes included the Hamilton Anxiety Rating Scale (HARS), a hemodynamic monitoring checklist, and the Pittsburgh Sleep Quality Index (PSQI), assessed at baseline and post-intervention. Data were analyzed using SPSS version 26 with descriptive and inferential statistical methods. Results: In the intervention group, mean heart rate, respiratory rate, blood pressure, and anxiety scores decreased significantly compared with the control group, whereas blood oxygen saturation increased significantly (P ≤ 0.05). Sleep quality indices in the EMDR group exhibited statistically significant improvements relative to the control group at both the one-month and three-month follow-up assessments (P = 0.001). Within-group analyses further confirmed notable pre- to post-intervention changes across the key outcome variables exclusively in the EMDR arm (P ≤ 0.05). In contrast, the control group displayed no statistically meaningful alterations in these parameters. Conclusion: Taken together, the present findings position EMDR as a clinically viable, rapidly applicable, and pharmacologically independent therapeutic option for patients hospitalized with ARI. https://ijps.tums.ac.ir/index.php/ijps/article/view/4438 https://ijps.tums.ac.ir/index.php/ijps/article/download/4438/1345