Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 3 1 2008 03 15 32 36 Mehri Gholami Mental Health Research Center,Tehran Psychiatric Institue, Iran University Medical Science,Tehran, Iran Hadi Teimoori Iran University Medical Science, Tehran, Iran Amir Shabani Mental Health Research Center,Tehran Psychiatric Institue, Iran University Medical Science,Tehran, Iran Morteza Naserbakht Mental Health Research Center,Tehran Psychiatric Institue, Iran University Medical Science,Tehran, IranNikan Health Research Center,Tehran,Iran Masood Ahmadzad Asl Mental Health Research Center,Tehran Psychiatric Institue, Iran University Medical Science,Tehran, Iran Nikan Health Research Center,Tehran,Iran 2015 10 17 Objective: Depression is the most common co-morbid psychiatric disorder in patients with epilepsy. Yet it remains under recognized and under-treated. For depression screening in this patient need to a convenient questionnaire for patients with epilepsy. This questionnaire has shown high sensitivity for depression screening in many studies. The center for Epidemiological Studies Depression Scale (CES-D) has been widely used in studies of late-life depression. The CES-D is easy to use in most settings. Method: Two groups of patients from two hospital centers were selected to participate in this study: the control group and the experimental group which included patients with approved diagnosis of epilepsy, regardless of any type of seizures. Then all the subjects went through a semi structural clinical interview for (SCID-I) DSM-IV by one psychiatrist. Consequently, all the patients completed the CES-D 10 items questionnaire along with the interview. In the two groups, the CESD scale cut-off point was obtained using ROC analysis. Results: The optimal cut-off score of CES-D in the both group was .3. Sensitivity, specificity, and positive predicted values in the epileptic group were 86.4%, 55.3%and 60% ; and sensitivity, specificity, and positive predictedvalues in the control group were 72.7% ,68.6%, 38.3% respectively. Conclusion: It appears that CES-D 10 items is an appropriate tool for screening patients with epilepsy, particularly if the multi-stage screening system is used with other methods. https://ijps.tums.ac.ir/index.php/ijps/article/view/465 https://ijps.tums.ac.ir/index.php/ijps/article/download/465/489