Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 9 4 2014 12 15 237 240 Youssef Fakour Assistant professor, Department of Psychiatry, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran Pedram Noormohammadpour Assistant professor, Department of Dermatology, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran Hamed Ameri Department of Biomedical engineering, Science and Research branch, Islamic Azad University, Tehran, Iran Amir Houshang Ehsani Assistant professor, Department of Psychiatry, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran Leila Mokhtari Master of Clinical Psychology, Ministry of Education Najmeh Khosrovanmehr Master of Clinical Psychology, Shahid Beheshti University of medical sciences, Imam Hussein Hospital Seyedeh Zahra Hoseini Nezhad Department of Dermatology, Tehran University of Medical Sciences, Razi hospital, Tehran, Iran 2015 10 14 Objective: Acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course . Methods: In this prospective study, 98 patients with severe acne were enrolled consecutively and underwent isotretinoin therapy receiving 0.5 mg/kg/d of isotretinoin for 16 weeks. Isotretinoin effects on quality of life and depression were evaluated using Dermatology Life Quality Index (DLQI) and Beck Depression Inventory (BDI) questionnaires, respectively. Results: In this study, 98 patients suffering from severe acne (38 males and 60 females) were enrolled. Treatment of acne was associated with improvement of quality of life scores in both male and female patients (p = 0.001). Considering the cutoff value of 13 for mild depressive mood in the BDI score, in total, 48 (49%) of the enrolled patients (21 males and 33 females) had a mild depressive mood before the commencement of the treatment in this study. The analysis of before and after treatment BDI scores showed that the number of patients and also the mean score of BDI were increased in both male and female patients after the treatment (p<0.05). Conclusion: Isotretinoin therapy improved the quality of life of patients suffering from https://ijps.tums.ac.ir/index.php/ijps/article/view/64 https://ijps.tums.ac.ir/index.php/ijps/article/download/64/60