Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 12 3 2017 06 28 201 205 EN Atieh Dolatian Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Seyed Masoud Arzaghi Elderly Health Research Center, Endocrinology and Metabolism population sciences Institute, Tehran university of Medical sciences, Tehran, Iran Mostafa Qorbani School of Medicine, Community Medicine Department, Alborz University of Medical Sciences, Karaj, Iran Hamideh Pishva Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran 2016 04 10 Objective: obesity and depression are likely to interact mutually which makes it unclear if obesity causes depression or it leads to obesity; and how the genotypes have a role in obesity and depression. Methods and Materials: This cross sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive Iranian Multicenter Osteoporosis Study (IMOS). Anthropometric measurements and depression were assessed. To investigate the NPY polymorphism, PCR-RFLP was used. Binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphism Results: the frequency of NPY rs16139 was 6%. No significant association could be found between NPY genotypes and depression (p >0.05). Furthermore, the results suggest that those with central obesity seem an increased chance of developing depression (P=0.02). Conclusion: There is a significant relationship between obesity and depression and obesity is a possible cause of depression. Waist circumference and abdominal obesity as components of metabolic syndrome have the most important effects on depression. https://ijps.tums.ac.ir/index.php/ijps/article/view/656 https://ijps.tums.ac.ir/index.php/ijps/article/download/656/644