Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 11 3 2016 10 09 173 177 EN Roya Najafi-Vosough Department of Biostatistics, School of Public Health, Hamadan University of Medical ‎Sciences, Hamadan, Iran. Ali Ghaleiha Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical ‎Sciences, Hamadan, Iran. Javad Faradmal Department of Biostatistics, School of Public Health, Hamadan University of Medical ‎Sciences, Hamadan, Iran. AND Modeling of Noncommunicable Disease Research Canter, Hamadan University of Medical Sciences, Hamadan, Iran. Hossein Mahjub Department of Biostatistics, School of Public Health, Hamadan University of Medical ‎Sciences, Hamadan, Iran. AND Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. 2016 08 23 2016 08 23 Objective: The aim of this study was to identify prognosis factors associated with recurrence in patients ‎with bipolar disorder.‎‎ Method: This retrospective cohort study was conducted in Hamadan Province, the west of Iran. All ‎patients (n = 400) with bipolar disorder who were hospitalized for the second time or more ‎during April 2008 to September 2014 were included in this study. Ordinal logistic regression ‎analysis was employed to determine the effective factors in each recurrence, and odds ratio (OR) and 95% confidence intervals (CI) were obtained.‎ Results: The mean (SD) age of the participants at the entrance to the study was 34.62 (11.68) years. ‎There was an association between recurrence and type of bipolar disorder (P = 0.033). The ‎OR of recurrence was 0.28 (95% CI: 0.09, 0.90) for bipolar disorder II; 0.35 (95% CI: 0.13, ‎‎0.92) for the patients‎‏ ‏with college education; 0.39 (95% CI: 0.25, 0.60) for employed ‎patients; 0.55 (95% CI: 0.35, 0.87) for patients who received both drugs and ‎electroconvulsive therapy, and 1.89 (95% CI: 1.23, 2.92) for patients who stopped using ‎drugs. In addition, a non-significant association was found between recurrence and age, sex, ‎marital status, place of residence, season, mood classification and family history of mood ‎disorder.‎ Conclusion: Type of bipolar disorder and cessation of medication were the leading causes of an increase in ‎the relapse of the disease. Furthermore, patients who received both drugs and ‎electroconvulsive therapy had a fewer risk of recurrence.‎ https://ijps.tums.ac.ir/index.php/ijps/article/view/773 https://ijps.tums.ac.ir/index.php/ijps/article/download/773/566