Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 11 3 2016 10 09 191 197 EN Mandana Nojoumi Department of Pharmacotherapy, Faculty of Pharmacy, Islamic Azad University of Pharmaceutical ‎Sciences, Tehran, Iran. Padideh Ghaeli Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, ‎Tehran, Iran. Samrand Salimi Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ali Sharifi Research Centre for Intelligent Signal Processing, Tehran, Iran. Firoozeh Raisi Psychiatric and Psychology Research Centre, Roozbeh Psychiatric Hospital, Tehran University of ‎Medical Sciences, Tehran, Iran. 2016 08 23 Objective: Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ‎effects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ‎flower standardized extract on reaction time in patients with generalized anxiety disorder.‎ Method: Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ‎fulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ‎measured at baseline and after one month of treatment using computerized software. Correct ‎responses, omission and substitution errors and the mean time of correct responses (reaction time) in ‎both visual and auditory tests were collected. The analysis was performed between the two groups ‎and within each group utilizing SPSS PASW- statics, Version 18. P-value less than 0.05 was ‎considered statistically significant.‎ Results: All the participants were initiated on Sertraline 50 mg/day, and the dosage was increased to 100 ‎mg / day after two weeks. Fourteen patients received Pasipy (Passion Flower) 15 drops three times ‎daily and 16 received placebo concurrently. Inter-group comparison proved no significant difference ‎in any of the test items between assortments while a significant decline was observed in auditory ‎omission errors in passion flower group after on month of treatment using intra-group analysis.‎‎ Conclusion: This study noted that passion flower might be suitable as an add-on in the treatment of generalized ‎anxiety disorder with low side effects. Further studies with longer duration are recommended to ‎confirm the results of this study.‎ https://ijps.tums.ac.ir/index.php/ijps/article/view/775 https://ijps.tums.ac.ir/index.php/ijps/article/download/775/573