Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 11 3 2016 10 09 147 153 EN Sadegh Yoosefee Neuroscience and Neurology Research Center, Qom University of Medical Sciences, Qom, ‎Iran. AND Department of Neuroscience, School of Advanced Technologies in Medicine, Iran ‎University of Medical Sciences ‎‎(IUMS), Tehran, Iran‎. AND Health and Religion Research Center, Qom University of Medical Sciences, Qom, Iran. Esmaeil Shahsavand Ananloo Department of Adult Psychiatry, Roozbeh Hospital, School of Medicine, Tehran University of ‎Medical Sciences (TUMS), ‎Tehran, Iran.‎AND Department of Genomic Psychiatry and Behavioral Genomics (DGPBG), Roozbeh ‎Psychiatry Hospital, School of ‎Medicine, Tehran University of Medical Sciences (TUMS), ‎Tehran, Iran. Mohammad-Taghi Joghataei Department of Neuroscience, School of Advanced Technologies in Medicine, Iran ‎University of Medical Sciences ‎‎(IUMS), Tehran, Iran‎. Morteza Karimipour Molecular Medicine Group, Pasteur Institute of Iran. Mahmoudreza Hadjighassem Department of Neuroscience and addiction studies, School of Advanced Technologies in Medicine, Tehran ‎University of Medical ‎Sciences (TUMS), Tehran, Iran. Hoorie Mohaghghegh Department of Neuroscience and addiction studies, School of Advanced Technologies in Medicine, Tehran ‎University of Medical ‎Sciences (TUMS), Tehran, Iran. Mehdi Tehrani-Doost Department of Child and Adolescent Psychiatry, Roozbeh Hospital, School of Medicine, ‎Tehran University of Medical Sciences (TUMS), Tehran, Iran. Amir-Abbas Rahimi Molecular Medicine Group, Pasteur Institute of Iran. Hamid Mostafavi Abdolmaleky Department of Genetics & Genomics, Boston University School of Medicine, Boston, MA, ‎United States. Maryam Hatami Department of Adult Psychiatry, Roozbeh Hospital, School of Medicine, Tehran University of ‎Medical Sciences (TUMS), ‎Tehran, Iran 2016 08 23 2016 08 23 Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the ‎pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 ‎is associated with schizophrenia and its negative symptoms in an Iranian population.‎ Method: Rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy controls. The association of genetic risk with PANSS, and negative ‎symptoms was examined in the total, male and female samples. COCAPHASE and ‎CLUMP22 programs were used to compare the allele and genotype frequencies, and ‎general linear regression was used to analyze the quantitative dependent variables by the ‎selected variant.‎ Results: In this study, it was revealed that the G allele of rs2439272 might be an allele with the ‎increased risk of developing schizophrenia, especially in the male participants. In addition, ‎significant differences were found between the G allele and GG genotype frequencies and ‎PANSS, and negative symptoms in the total and male participants.‎ Conclusion: Our results supported the association between rs2439272 in NRG1 gene and risk of ‎schizophrenia and its negative symptoms in an Iranian population. https://ijps.tums.ac.ir/index.php/ijps/article/view/778 https://ijps.tums.ac.ir/index.php/ijps/article/download/778/575