Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 1 3 Shahin Akhondzadeh Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran Afshar Amiri Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran Amir Houshang Bagheri Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran 2015 10 14 Objective: TThe objective of this study was to assess the efficacy and safety of SX (combination of yohimbine and L-arginine) in the treatment of erectile dysfunction (ED) Methods: This trial was a 4-week, double blind study of parallel groups of patients with mild to moderate ED. Forty married male patients with ED of mild-to-moderate severity were screened for the study entry;among them, those aged 25-50 who reported a minimum of a- 3-month history of ED were eligible to enroll in this study. The severity of ED was based on EF domain scores on the international index of erectile function (IIEF). The scores of 15-25 was considered as mild to moderate ED. Patients were randomized to receive one capsule of SX or placebo on demand in a 1:1 ratio using a computer-generated code.The difference between the two groups was significant at week 4 (endpoint) (P=0.03). Four adverse events were observed over the study. Results: The difference between the SX and placebo was not significant in the frequency of adverse events. Conclusion: This study indicates that SX is safe and effective for the treatment of mild to moderate ED at least in the short-term. https://ijps.tums.ac.ir/index.php/ijps/article/view/384 https://ijps.tums.ac.ir/index.php/ijps/article/download/384/380

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 4 6 Firoozeh Raisi Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Departmen of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Vahid Farnia Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Nafiseh Ghanbarian Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Z Ghafuri Departmen of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: We conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigRX) on premature ejaculation (PE). Method: A randomized double blind study was conducted on a fixed dose of herbal vigRX at Roozbeh Psychiatry Hospital, Tehran University of Medical Sciences. The sample consisted of 85 married patients diagnosed with primary PE according to Diagnostic and Statistical Manual of Mental Disorders. Each patient underwent diagnostic evaluation by one trained psychiatrist, using Structured Clinical Interview for DSM-IV-TR. Each patient was evaluated by researchers to exclude the organic sexual dysfunctions. The patients were randomly assigned in to two groups: group 1 consisting of 42 patients receiving placebo, and group 2 consisting of 43 patients receiving 540 mg herbal vigRX for a 4-week treatment course. The effects of the drug on the ejaculatory function in each group were assessed by the intravaginal ejaculation latency time (IELT), and the Chinese Index of Premature Ejaculation (CIPE) before and at the end of the treatment course. Statistical analysis was performed using SPSS software (15th version).The mean IELT increased 22.4 and 32.0 seconds in the placebo and the vigRX group respectively after the treatment course. The mean IELT differences between the two groups was not significant. The mean CIPE score increased 2.40 and 4.37 in the placebo and the vigRX group respectively. Results: The mean CIPE score differences between the two groups was not significant.No side effect was reported by the subjects in neither groups during the treatment course. Conclusion: Although the improvement in IELT and CIPE scores in the herbal vigRX group was more than the placebo group, this difference was not statistically significant. The increasing of IELT and CIPE score in the placebo group may be due to the placebo effects. Further studies with higher vigRX doses, greater sample size and longer treatment courses are warranted. https://ijps.tums.ac.ir/index.php/ijps/article/view/383 https://ijps.tums.ac.ir/index.php/ijps/article/download/383/379

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 7 10 Yasaman Mottaghipour Department of Psychiatry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar Salesian Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Arshia Seddigh Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Mohsen Jalali Roudsari Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Sahar Tahbaz Hosseinzade Department of Psychology, Tehran University, Tehran, Iran Vandad Sharifi Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran 2015 10 14 Objective: The  implementation of  family  psychoeducation at  the  service delivery level is not without difficulty. Few mental health professionals receive special training to work with families especially in Iran.   The aim of the present study was to evaluate the effectiveness of training health professionals in terms of their adherence to protocol. Method: Eight professionals (general practitioners, nurses and social workers) participated in a training program for health professionals as part of the Roozbeh First-Episode Psychosis Program  (RooF) to  conduct family psychoeducation. Training included a 3-day- workshop and 12 supervision sessions during the course of the implementation of the psychoeducation program. The family psychoeducation sessions (multiple-family group or single-family home-based) were tape-recorded. Transcripts of the audiotaped sessions were analyzed based on the content of the manual and were scored accordingly. Results: Twenty-four recorded sessions were analyzed in terms of th  adherence  to  protocol,  the  number  of  questions  and  the  time  for  each session.  The  overall  rating  showed  a  72%  adherence  to  the  protocol. Multiple-family group sessions had a higher rate compared to the single- family home-based family psychoeducation sessions (79% to 69%) as well as the time spent and questions asked. The rate of adherence to the protocol of conducting the family psychoeducation sessions had not changed over time . Conclusion: Considering the amount of time taken for training and supervision, the level of adherence to the protocol was satisfactory. Tape recording sessions and  regular  supervision would be  beneficial following specialized  training.  Further  research  is  needed  to  tailor  the  amount  of training and supervision required for professionals to conduct family psychoeducation programs in different settings. https://ijps.tums.ac.ir/index.php/ijps/article/view/382 https://ijps.tums.ac.ir/index.php/ijps/article/download/382/378

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 11 17 Mohammad-Reza Zarrindast Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran Institute for Cognitive Science Studies, Tehran, Iran Saba Taheri Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Ameneh Rezayof Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran 2015 10 14 Objective: The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of the NAc is involved in anxiety-related behaviors. Methods:   Rats   were   anesthetized   with   intra-peritoneal   injection   of ketamine  hydrochloride,  plus  xylazine  and  then   were  placed  in  a stereotaxic  apparatus.  In  addition,  two  stainless-steel  cannuale  were placed 2 mm above the nucleus accumbens shell. Seven days after recovery from surgery, the behavioral testing was started.  As a model of anxiety, the elevated plus maze which is a useful test to investigate the effects of anxiogenic or anxiolytic drugs in rodents, was used in male Wistar rats. Results: Intra-NAc administration of histamine (0.01, 0.1 and 1 µg/rat) increased the percentage of open arm time (%OAT) and open arm entries (%OAE)  ,but  not  locomotor  activity,  indicating  an  anxiolytic  response. Furthermore, bilateral microinjections of different doses of the H1 receptor antagonist pyrilamine (0.001, 0.01, 0.1 and 1 µg/rat) or the H2  receptor antagonist ranitidine (0.001, 0.01, 0.1 and 1 µg/rat) into the NAc increased %OAT and %OAE , but not locomotor activity. However, both histamine and histamine receptor antagonists showed an anxiolytic-like effect ; the antagonists (1 µg/rat) also decreased the histamine response. Conclusion: The results may indicate a modulatory effect for the H1  and H2  histamine receptors of nucleus accumbens in the anxiety behavior of rats. https://ijps.tums.ac.ir/index.php/ijps/article/view/381 https://ijps.tums.ac.ir/index.php/ijps/article/download/381/377

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 18 22 Toktam Faghihi Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Padideh Ghaeli Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Adel Jahed Department of Endocrinology and Internal Medicine, Boo-ali University Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, Iran Javad Mahmoudi-Gharaei Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Vandad Sharifi Department of Psychiatry, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Akhondzadeh Shahin Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: Metabolic side effects of the second generation (atypical) antipsychotics have been a forefront of attention since their availability. One common   concern   is   the   development   of   hyperglycemia   and   insulin resistance. The aim of this study was to evaluate the effect of early initiation of omega-3 fatty acids supplementation on glucose-insulin homeostasis in a group of psychiatric patients under treatment with olanzapine and sodium valproate or lithium combination. Method: In a double-blind design, eligible participants with schizophrenia, bipolar I, and schizoaffective disorders who were initiated on olanzapine combination  with  sodium  valproate  or  lithium were randomly assigned to receive omega-3 or identical placebo capsules for 6 weeks. Fasting blood sugar (FBS), insulin and HbA1c  were measured at the baseline and at the end of the 6th  week. Homeostatic model assessment of insulin resistance (HOMA-IR), as a measure of insulin resistance, was also determined at the same times. Results: At the end of the study, no significant difference was observed between the two arms in terms of FBS, fasting insulin, HbA1c and HOMA-IR. However, trends toward decreasing both fasting insulin levels (p= 0.06) and HOMA-IR  (p=  0.07)  were  noted  in  the  group  receiving  omega-3.  No significant  changes  in  the  outcome  variables  were  observed  from  the baseline to the final measurements in both groups. Conclusion: This study noted that adding omega-3 fatty acids at the commencement of olanzapine combination therapy with valproate or lithium could not favorably influence glucose-insulin homeostasis. However, trends toward a decrease in insulin levels (p= 0.06) and HOMA-IR (p= 0.07) observed in patients receiving omega-3 suggest a possible beneficial role of this supplement in this population and, therefore, warrant further evaluation. https://ijps.tums.ac.ir/index.php/ijps/article/view/380 https://ijps.tums.ac.ir/index.php/ijps/article/download/380/376

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 23 27 Javad Mahmoodi-Gharaei Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Anahita Basirnia Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Neda Abedi Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Behrang Shadloo Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Sara Jafari Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Niloofar Salesian Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Mohsen Djalali Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Vandad Sharifi Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: Poor premorbid adjustment has been reported to be a predictor of more severe psychotic symptoms and poor quality of life in such psychotic disorders  as  schizophrenia.  However,  most  studies  were  performed  on chronic schizophrenic patients, and proposed the likelihood of recall biases and the effect of chronicity.  The aim of this study was to investigate 02 06 Objective: The Social Responsiveness Scale-2 (SRS-2) is a well-known screening instrument to assess autistic spectrum symptoms quantitatively. This study assessed the different types of reliability of the Farsi translation of the scale. Method: This scale was translated into Farsi and back translated considering all aspects of methodology in translation. Then, based on stratified sampling, 533 7-11-year-old students were randomly selected from the mainstream schools located in the central parts of Tehran, the capital of Iran. For all the students, SRS-2 was completed by both the parents and teachers. To check retest reliability, the test was administered again for 15% of the total participants after a 2-4 week-period. Cronbach’s alpha coefficient, split-half” and Gottman” methods, and intra-class correlation coefficient (ICC) were used. Results: The mean total raw score was 48.47 (±23.63) and 53.17 (±27.33) in the sequence of the parents and teachers’ reports. The internal consistency (Cronbach’s alpha; 0.86 and 0.89), test-retest reliability (ICC; 0.72 and 0.83 for parents and teacher’ ratings, respectively), and interrater reliability (ICC; 0.72) showed well-accepted measurement performance. Conclusion: The findings indicated that the Farsi SRS-2 can be used as a reliable instrument to measure social responsiveness as autistic symptoms in Iranian child population. https://ijps.tums.ac.ir/index.php/ijps/article/view/1669 https://ijps.tums.ac.ir/index.php/ijps/article/download/1669/901

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 15 1 2020 02 10 47 54 EN Samira Hashemi Health Research Institute, Diabetes Research Centre, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Reza Amani Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Bahman Cheraghian Department of Biostatistics and Epidemiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Sorour Neamatpour Department of Psychiatry, Golestan Medical Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2017 08 12 Objective: Recent studies have revealed that fatty acid profile can be associated with psychological disorders. However, evidence on stress and anxiety is scarce. The aim of this study was to investigate the relationship between stress and anxiety, defined as mood states, and erythrocyte fatty acid (FA) profile. Method: This case-control study was conducted on 45 female students with degrees of stress and anxiety without depression disorder and 45 matched controls with no depression, stress, or anxiety. Self-administered questionnaires included a 28-item Food Frequency questionnaire and Depression Anxiety Stress Scales (DASS-21), which were used to measure dietary patterns and psychological disorders, respectively. Erythrocyte membrane fatty acids were analyzed using gas-liquid chromatography. Results: Docosahexaenoic acid (DHA) was significantly lower in the case group (p = 0.008). Hydrogenated fats were associated with degrees of stress and anxiety (OR = 1.53, p = 0.019), while linoleate and DHA were inversely associated with stress and anxiety scores (OR = 0.37, p = 0.05; OR = 0.31, p = 0.014, respectively). Monounsaturated FAs (MUFAs) and total RBC trans FA were associated with increased risk of stress and anxiety (OR = 1.81, p < 0.001; OR = 3.38, p = 0.003, respectively). Conclusion: Trans-fatty acids may be related to stress and anxiety scales but linoleate and DHA could decrease the risk. The effect of MUFAs may be regarded as a result of compensatory biological mechanisms. https://ijps.tums.ac.ir/index.php/ijps/article/view/1169 https://ijps.tums.ac.ir/index.php/ijps/article/download/1169/902

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 15 1 2020 02 10 55 66 Mohammad Effatpanah School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Science, Tehran, Iran. Mohammad Moharrami School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Gilda Rajabi Damavandi Ziaeian Hospital, Tehran University of Medical Science, Tehran, Iran. Mahdi Aminikhah Department of Epidemiology and Biostatistics, School of Public health, Tehran University of Medical Science, Tehran, Iran. Mohammad Hosein Nezhad Farhangiyan University, Tehran, Iran. Farnaz Khatami Family Medicine Department, Ziaeian Hospital, Tehran University of Medical Science, Tehran, Iran. Tara Arjmand Ziaeian Hospital, Tehran University of Medical Science, Tehran, Iran. Heliya Tarighatnia Ziaeian Hospital, Tehran University of Medical Science, Tehran, Iran. <