Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 1 3 Shahin Akhondzadeh Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran Afshar Amiri Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran Amir Houshang Bagheri Psychiatry & psychology Research Center, Roozbeh Hospital, Tehran University of Medical Center, Tehran, Iran 2015 10 14 Objective: TThe objective of this study was to assess the efficacy and safety of SX (combination of yohimbine and L-arginine) in the treatment of erectile dysfunction (ED) Methods: This trial was a 4-week, double blind study of parallel groups of patients with mild to moderate ED. Forty married male patients with ED of mild-to-moderate severity were screened for the study entry;among them, those aged 25-50 who reported a minimum of a- 3-month history of ED were eligible to enroll in this study. The severity of ED was based on EF domain scores on the international index of erectile function (IIEF). The scores of 15-25 was considered as mild to moderate ED. Patients were randomized to receive one capsule of SX or placebo on demand in a 1:1 ratio using a computer-generated code.The difference between the two groups was significant at week 4 (endpoint) (P=0.03). Four adverse events were observed over the study. Results: The difference between the SX and placebo was not significant in the frequency of adverse events. Conclusion: This study indicates that SX is safe and effective for the treatment of mild to moderate ED at least in the short-term. https://ijps.tums.ac.ir/index.php/ijps/article/view/384 https://ijps.tums.ac.ir/index.php/ijps/article/download/384/380

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 4 6 Firoozeh Raisi Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Departmen of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Vahid Farnia Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Nafiseh Ghanbarian Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Z Ghafuri Departmen of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: We conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigRX) on premature ejaculation (PE). Method: A randomized double blind study was conducted on a fixed dose of herbal vigRX at Roozbeh Psychiatry Hospital, Tehran University of Medical Sciences. The sample consisted of 85 married patients diagnosed with primary PE according to Diagnostic and Statistical Manual of Mental Disorders. Each patient underwent diagnostic evaluation by one trained psychiatrist, using Structured Clinical Interview for DSM-IV-TR. Each patient was evaluated by researchers to exclude the organic sexual dysfunctions. The patients were randomly assigned in to two groups: group 1 consisting of 42 patients receiving placebo, and group 2 consisting of 43 patients receiving 540 mg herbal vigRX for a 4-week treatment course. The effects of the drug on the ejaculatory function in each group were assessed by the intravaginal ejaculation latency time (IELT), and the Chinese Index of Premature Ejaculation (CIPE) before and at the end of the treatment course. Statistical analysis was performed using SPSS software (15th version).The mean IELT increased 22.4 and 32.0 seconds in the placebo and the vigRX group respectively after the treatment course. The mean IELT differences between the two groups was not significant. The mean CIPE score increased 2.40 and 4.37 in the placebo and the vigRX group respectively. Results: The mean CIPE score differences between the two groups was not significant.No side effect was reported by the subjects in neither groups during the treatment course. Conclusion: Although the improvement in IELT and CIPE scores in the herbal vigRX group was more than the placebo group, this difference was not statistically significant. The increasing of IELT and CIPE score in the placebo group may be due to the placebo effects. Further studies with higher vigRX doses, greater sample size and longer treatment courses are warranted. https://ijps.tums.ac.ir/index.php/ijps/article/view/383 https://ijps.tums.ac.ir/index.php/ijps/article/download/383/379

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 7 10 Yasaman Mottaghipour Department of Psychiatry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar Salesian Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Arshia Seddigh Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Mohsen Jalali Roudsari Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran Sahar Tahbaz Hosseinzade Department of Psychology, Tehran University, Tehran, Iran Vandad Sharifi Department of Psychiatry, Psychiatry and Psychology Research Center, Tehran University of Med ical Sciences, Tehran, Iran 2015 10 14 Objective: The  implementation of  family  psychoeducation at  the  service delivery level is not without difficulty. Few mental health professionals receive special training to work with families especially in Iran.   The aim of the present study was to evaluate the effectiveness of training health professionals in terms of their adherence to protocol. Method: Eight professionals (general practitioners, nurses and social workers) participated in a training program for health professionals as part of the Roozbeh First-Episode Psychosis Program  (RooF) to  conduct family psychoeducation. Training included a 3-day- workshop and 12 supervision sessions during the course of the implementation of the psychoeducation program. The family psychoeducation sessions (multiple-family group or single-family home-based) were tape-recorded. Transcripts of the audiotaped sessions were analyzed based on the content of the manual and were scored accordingly. Results: Twenty-four recorded sessions were analyzed in terms of th  adherence  to  protocol,  the  number  of  questions  and  the  time  for  each session.  The  overall  rating  showed  a  72%  adherence  to  the  protocol. Multiple-family group sessions had a higher rate compared to the single- family home-based family psychoeducation sessions (79% to 69%) as well as the time spent and questions asked. The rate of adherence to the protocol of conducting the family psychoeducation sessions had not changed over time . Conclusion: Considering the amount of time taken for training and supervision, the level of adherence to the protocol was satisfactory. Tape recording sessions and  regular  supervision would be  beneficial following specialized  training.  Further  research  is  needed  to  tailor  the  amount  of training and supervision required for professionals to conduct family psychoeducation programs in different settings. https://ijps.tums.ac.ir/index.php/ijps/article/view/382 https://ijps.tums.ac.ir/index.php/ijps/article/download/382/378

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 11 17 Mohammad-Reza Zarrindast Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran Institute for Cognitive Science Studies, Tehran, Iran Saba Taheri Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Ameneh Rezayof Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran 2015 10 14 Objective: The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of the NAc is involved in anxiety-related behaviors. Methods:   Rats   were   anesthetized   with   intra-peritoneal   injection   of ketamine  hydrochloride,  plus  xylazine  and  then   were  placed  in  a stereotaxic  apparatus.  In  addition,  two  stainless-steel  cannuale  were placed 2 mm above the nucleus accumbens shell. Seven days after recovery from surgery, the behavioral testing was started.  As a model of anxiety, the elevated plus maze which is a useful test to investigate the effects of anxiogenic or anxiolytic drugs in rodents, was used in male Wistar rats. Results: Intra-NAc administration of histamine (0.01, 0.1 and 1 µg/rat) increased the percentage of open arm time (%OAT) and open arm entries (%OAE)  ,but  not  locomotor  activity,  indicating  an  anxiolytic  response. Furthermore, bilateral microinjections of different doses of the H1 receptor antagonist pyrilamine (0.001, 0.01, 0.1 and 1 µg/rat) or the H2  receptor antagonist ranitidine (0.001, 0.01, 0.1 and 1 µg/rat) into the NAc increased %OAT and %OAE , but not locomotor activity. However, both histamine and histamine receptor antagonists showed an anxiolytic-like effect ; the antagonists (1 µg/rat) also decreased the histamine response. Conclusion: The results may indicate a modulatory effect for the H1  and H2  histamine receptors of nucleus accumbens in the anxiety behavior of rats. https://ijps.tums.ac.ir/index.php/ijps/article/view/381 https://ijps.tums.ac.ir/index.php/ijps/article/download/381/377

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 18 22 Toktam Faghihi Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Padideh Ghaeli Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Adel Jahed Department of Endocrinology and Internal Medicine, Boo-ali University Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, Iran Javad Mahmoudi-Gharaei Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Vandad Sharifi Department of Psychiatry, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Akhondzadeh Shahin Psychiatry and Psychology Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: Metabolic side effects of the second generation (atypical) antipsychotics have been a forefront of attention since their availability. One common   concern   is   the   development   of   hyperglycemia   and   insulin resistance. The aim of this study was to evaluate the effect of early initiation of omega-3 fatty acids supplementation on glucose-insulin homeostasis in a group of psychiatric patients under treatment with olanzapine and sodium valproate or lithium combination. Method: In a double-blind design, eligible participants with schizophrenia, bipolar I, and schizoaffective disorders who were initiated on olanzapine combination  with  sodium  valproate  or  lithium were randomly assigned to receive omega-3 or identical placebo capsules for 6 weeks. Fasting blood sugar (FBS), insulin and HbA1c  were measured at the baseline and at the end of the 6th  week. Homeostatic model assessment of insulin resistance (HOMA-IR), as a measure of insulin resistance, was also determined at the same times. Results: At the end of the study, no significant difference was observed between the two arms in terms of FBS, fasting insulin, HbA1c and HOMA-IR. However, trends toward decreasing both fasting insulin levels (p= 0.06) and HOMA-IR  (p=  0.07)  were  noted  in  the  group  receiving  omega-3.  No significant  changes  in  the  outcome  variables  were  observed  from  the baseline to the final measurements in both groups. Conclusion: This study noted that adding omega-3 fatty acids at the commencement of olanzapine combination therapy with valproate or lithium could not favorably influence glucose-insulin homeostasis. However, trends toward a decrease in insulin levels (p= 0.06) and HOMA-IR (p= 0.07) observed in patients receiving omega-3 suggest a possible beneficial role of this supplement in this population and, therefore, warrant further evaluation. https://ijps.tums.ac.ir/index.php/ijps/article/view/380 https://ijps.tums.ac.ir/index.php/ijps/article/download/380/376

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 23 27 Javad Mahmoodi-Gharaei Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Anahita Basirnia Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Neda Abedi Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Behrang Shadloo Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Sara Jafari Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Niloofar Salesian Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Mohsen Djalali Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran Vandad Sharifi Roozbeh Hospital, Psychiatry Department, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Objective: Poor premorbid adjustment has been reported to be a predictor of more severe psychotic symptoms and poor quality of life in such psychotic disorders  as  schizophrenia.  However,  most  studies  were  performed  on chronic schizophrenic patients, and proposed the likelihood of recall biases and the effect of chronicity.  The aim of this study was to investigate these factors in a sample of first episode psychotic patients, as a part of Roozbeh first episode psychosis project (RooF). Method: Premorbid adjustment was assessed using Premorbid Adjustment Scale (PAS) in 48 patients with the first psychotic episode who were admitted to Roozbeh Psychiatric Hospital. The severity of symptoms was measured using Positive and Negative Scale (PANSS) in three subgroups of positive, negative and general subscales. Quality of life was measured using WHO QOL ,and Global Assessment of Functioning (GAF) was also measured. Results: The mean age was 24 years. Poor Premorbid adjustment in late adolescence  was  significantly  associated with  more  severe  symptoms according  to  PANSS  negative symptoms  (p=0.019,  r=0.44).  Furthermore, sociability  and  peer  relationship  domains  had  a  positive  correlation  with PANSS negative subscale scores (r=0.531, p=0.002 and r=0.385, p=0.03, respectively).  There  were  no  significant  differences  between  males  and females in premorbid adjustment. Furthermore, this study failed to show any differences  between  affective  and  non-affective  psychosis  in  premorbid functioning. Conclusion: Our study confirms poor premorbid adjustment association with more  severe  negative  symptoms  and  poor  quality of  life in  a sample of Iranian first episode psychotic patients. https://ijps.tums.ac.ir/index.php/ijps/article/view/379 https://ijps.tums.ac.ir/index.php/ijps/article/download/379/375

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 28 34 Alireza Agha Yousefi Assistant professor of Payame Noor University, Qom, Iran Nasim Sharif Payam-e- Noor University, Tehran ,Iran 2015 10 14 Objective: This study was conducted to compare the personal well-being among the wives of Iranian veterans living in the city of Qom. Method: A sample of 300 was randomly selected from a database containing the addresses of veteran’s families at Iran’s Veterans Foundation in Qom (Bonyad-e-Shahid va Omoore Isargaran).The veterans' wives were divided into three groups: wives of martyrs (killed veterans), wives of prisoners of war, and wives of disabled veterans.The Persian translation of Personal Well-being Index  and Stress Symptoms Checklist (SSC) were administered for data collection.  Four women chose not to respond to Personal Well-being Index. Data  were  then  analyzed  using  linear  multivariate  regression (stepwise method), analysis of variance, and by computing the correlation between variables. Results: Results showed a negative correlation between well-being and stress symptoms. However, each group demonstrated different levels of stress symptoms.  Furthermore, multivariate linear regression in the 3 groups showed that overall satisfaction of life and personal well-being (total score and its domains) could be predicted by different symptoms. Conclusion:  Each group experienced different challenges and thus different stress symptoms.  Therefore, although they all need help, each group needs to be helped in a different way. https://ijps.tums.ac.ir/index.php/ijps/article/view/378 https://ijps.tums.ac.ir/index.php/ijps/article/download/378/374

Tehran University of Medical Sciences Iranian Journal of Psychiatry 1735-4587 5 1 2010 03 15 35 39 Anahita Khodabakhshi Koolaee University of Social Welfare and Rehabilitation Sciences Nastaran Adibrad University of Social Welfare and Rehabilitation Sciences Bahram Saleh Sedgh Poor University of Social Welfare and Rehabilitation Sciences 2015 10 14 Objective: The aim of this study was to examine the comparison of relationship beliefs and couples burnout in women who apply for divorce and women who want to continue their marital life. Method: for this study, 50 women who referred to judicial centers and 50 women who claimed they wanted to continue their marital life were randomly selected. Participants were asked to complete the relationship beliefs inventory and marital burnout questionnaires. In this study, descriptive statistical methods such as standard deviation, mean, t- students for independent groups, correlation, multi-variable regression and independent group’s correlation difference test were used. Results: The comparison between the relationship beliefs of the 2 groups( those wanting to divorce and women wanting to continue their marital life) was  significantly  different(p<0/1). In addition,  the  comparison  of  marital burnout was significantly different in the 2 groups (p<0/1). Discussion: Women who were about to divorce were significantly different from those who wanted to continue their marital relationship in the general measure  of   the   relationship   beliefs   and   factors  of  " believing  that disagreement is destructive and their partners can not change their undesirable  behaviors".  In  other  words,  women  who  were  applying  for divorce had more unreasonable thoughts and burnout compared to those who wanted to continue their marital life. https://ijps.tums.ac.ir/index.php/ijps/article/view/377 https://ijps.tums.ac.ir/index.php/ijps/article/download/377/373