Determining Pro-Oxidant Antioxidant Balance (PAB) and Total Antioxidant Capacity (TAC) in Patients with Schizophrenia

  • Farnaz Zahei Avval Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Niloufar Mahmoudi Department of Psychiatry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Abolfazl Nosrati Tirkani Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Lida Jarahi Department of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Daryoush Hamidi Alamdari Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Seyed Alireza Sadjadi Department of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.and Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords: Pro-Oxidant Antioxidant Balance, Reactive Oxygen Species, Schizophrenia, Total Antioxidant Capacity

Abstract

Objective: Schizophrenia is a disease with unknown etiology. There is evidence suggesting that oxidative damage occurs in schizophrenia. Oxidative damage may arouse from imbalance between oxidant and anti-oxidant factors in cellular and tissue environment. Although it may not be the primary cause, it can worsen the disease and may be a reason of poor response to therapy in these patients. The present study aimed at evaluating the pro-oxidant antioxidant balance (PAB) and total antioxidant capacity (TAC) in serum of schizophrenia patients. PAB is an assay to determine the pro-oxidant load and antioxidant capacity in a single measurement.Method: In this cross- sectional study, patients with diagnosis of schizophrenia, who referred to a psychiatry university hospital (Ibn-e-Sina Hospital) affiliated to Mashhad University of Medical Sciences, were enrolled. Patients' demographic characteristics and laboratory data were recorded from patients’ files. Serum PAB and TAC were measured using a special PAB assay and commercial kit, respectively. Data were analyzed using SPSS 16.Results: A total of 84 individuals (42 schizophrenia cases and 42 healthy controls) participated in this study. Controls were age and sex-matched with the patients’ group. The mean TAC in the patient and control groups was 0.49±0.04 and 0.51±0.04 nmol/L, respectively (p = 0.16). PAB was higher in patients’ group than in controls (127.36±36.44 vs. 118.93±52.34 HK), however, this difference was not statistically significant (p = 0.09). The change was correlated with the chronicity of the disease.Conclusion: Pro-oxidant antioxidant balance was elevated in serum of patients with schizophrenia. These data suggested the occurrence of oxidative stress during the progression of the disease. Lower antioxidant capacity might suggest that patients with schizophrenia could be more susceptible to oxidative stress damage.

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Published
2018-06-14
How to Cite
1.
Zahei Avval F, Mahmoudi N, Nosrati Tirkani A, Jarahi L, Hamidi Alamdari D, Sadjadi SA. Determining Pro-Oxidant Antioxidant Balance (PAB) and Total Antioxidant Capacity (TAC) in Patients with Schizophrenia. ijps. 13(3):222-6.
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Short Communication(s)