Effects of Herbal vigRX on Premature Ejaculation: A randomized, double-blind study.
AbstractObjective: We conducted a double-blind, placebo-controlled study to determine the efficacy of an herbal sexual supplement (vigRX) on premature ejaculation (PE).Method: A randomized double blind study was conducted on a fixed dose of herbal vigRX at Roozbeh Psychiatry Hospital, Tehran University of Medical Sciences. The sample consisted of 85 married patients diagnosed with primary PE according to Diagnostic and Statistical Manual of Mental Disorders. Each patient underwent diagnostic evaluation by one trained psychiatrist, using Structured Clinical Interview for DSM-IV-TR. Each patient was evaluated by researchers to exclude the organic sexual dysfunctions. The patients were randomly assigned in to two groups: group 1 consisting of 42 patients receiving placebo, and group 2 consisting of 43 patients receiving 540 mg herbal vigRX for a 4-week treatment course. The effects of the drug on the ejaculatory function in each group were assessed by the intravaginal ejaculation latency time (IELT), and the Chinese Index of Premature Ejaculation (CIPE) before and at the end of the treatment course. Statistical analysis was performed using SPSS software (15th version).The mean IELT increased 22.4 and 32.0 seconds in the placebo and the vigRX group respectively after the treatment course. The mean IELT differences between the two groups was not significant. The mean CIPE score increased 2.40 and 4.37 in the placebo and the vigRX group respectively.Results: The mean CIPE score differences between the two groups was not significant.No side effect was reported by the subjects in neither groups during the treatment course.Conclusion: Although the improvement in IELT and CIPE scores in the herbal vigRX group was more than the placebo group, this difference was not statistically significant. The increasing of IELT and CIPE score in the placebo group may be due to the placebo effects. Further studies with higher vigRX doses, greater sample size and longer treatment courses are warranted.
Montorsi F. Prevalence of premature ejaculation: a global and regional perspective. J Sex Med 2005; 2 : 96-102.
Basile Fasolo C, Mirone V, Gentile V, Parazzini F, Ricci E; Andrology Prevention Week centers, et al.Premature ejaculation: prevalence and associated conditions in a sample of 12 558 men attending the andrology prevention week 2001-- a study of the Italian Society of Andrology (SIA). J Sex Med 2005; 2: 376-382.
Screponi E, Carosa E, Di Stasi SM, Pepe M, Carruba G, Jannini EA. Prevalence of chronic prostatitis in men with premature ejaculation. Urology 2001; 58: 198-202.
McMahon CG. Treatment of premature ejaculation with sertralin hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998; 159: 1935-1938.
Sadock BJ. Abnormal sexuality and sexual dysfunctions. In: sadock BJ, sadock V,eds. synopsis of psychiatry, Philadelphia : lippincott Williams& wilkins;2003.
Hsu JH, Shen WW. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry Med 1995; 25: 191 – 201.
Shen WW, Hsu JH. Female sexual side effects associated with selective serotonin reuptake inhibitors: a descriptive clinical study of 33 patients. Int J Psychiatry Med 1995; 25:239 – 248.
Kowalsky A, Stanley RO, Dennerstein L, Burrows G , Maguire KP . The sexual side effects of antidepressant medication: a double blind comparison of two antidepressants in a nonpsychiatric population. Br J Psychiatry 1985; 147: 413 – 418.
Rosen RC, Lane RM, Menza M: Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 1999; 19:67–85
Rowland DL, Tai W. A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. J Sex Marital Ther 2003;29:185-205.
Kelly JP, Kaufman DW, Kelley K, Rosenberg L, Anderson TE, Mitchell AA. Recent trends in use of herbal and other natural products. Arch Intern Med 2005;165:281-286.
Crimmel AS, Conner CS, Monga M. Withered Yang: A Review of Traditional Chinese Medical Treatment of Male Infertility and Erectile Dysfunction. J Androl 2001; 22: 173- 182.
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Premature Ejaculation - Help for men. Available from: http://www.fixpe.com/
Yuan YM, Xin ZC, Jiang H, Guo YJ, Liu WJ, Tian L, et al. Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation. Asian J Androl 2004; 6: 121-126.
Cohen AJ, Bartlik B. Ginkgo Biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1988; 24;139-143.
Wheatley D. Triple–blind, placebo-controlled trial of ginkgo biloba in sexual dysfunction due to antidepressant drugs. Hum Psychopharmacol 2004; 19: 545-548.
Waynberg J, Brewer S. Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther 2000; 17: 255-262.