Iranian Journal of Psychiatry 2016. 11(4):257-261.

Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia
Hasan Soltani, Serwa Mohammadzadeh, Manoochehr Makvandi, Siroos Pakseresht, Alireza Samarbaf-Zadeh

Abstract


Objective: Schizophrenia is a complex widespread neuropsychiatric disorder. This illness encompasses a complex debilitating mental disorder causing illusion, delusion, disturbed relationship, low motivation and decline of emotion. Viral infection of the brain including Borna Disease Virus (BDV) may play a role in transient or permanent neurological and behavioral abnormalities. This role of Borna virus has not been resolved outright yet, and based on published papers investigation examining the role of this virus in schizophrenia is in progress worldwide.

Method: In this study, Nested Reverse Transcription–Polymerase Chain Reaction (Nested RT-PCR) was used for detection of BDV Ribonucleic Acid (RNA) in Peripheral Blood Mononuclear Cells (PBMCs) of a group of patients experiencing the first episode of schizophrenia. The results were compared with a normal group.

Results: In our study, no BDV-positive was found in PBMCs of the case group. Out of 40 participants of control group one was positive for P24 gene of BDV. This result are similar to several published papers about this topic.

Conclusion: An etiological relationship between Bornavirus and schizophrenia was not found in this study. More investigations are warranted to illustrate the probable relationship between bornavirus infection and schizophrenia.


Keywords


BDV; Nested RT-PCR; Schizophrenia

Full Text:

PDF

References


Nunes SO, Itano EN, Amarante MK, Reiche EM, Miranda HC, de Oliveira CE, et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal 2008; 22: 314-320.

McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2004; 2: 13.

Saha S, Chant D, Welham J, McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med 2005; 2: e141.

Suvisaari J, Mautemps N, Haukka J, Hovi T, Lonnqvist J. Childhood central nervous system viral infections and adult schizophrenia. Am J Psychiatry 2003; 160: 1183-1185.

van den Pol AN. Viral infection leading to brain dysfunction: more prevalent than appreciated? Neuron 2009; 64: 17-20.

Terayama H, Nishino Y, Kishi M, Ikuta K, Itoh M, Iwahashi K. Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res 2003; 120: 201-206.

Hornig M, Lipkin WI. Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models. Ment Retard Dev Disabil Res Rev 2001; 7: 200-210.

Carbone KM, Rubin SA, Nishino Y, Pletnikov MV. Borna disease: virus-induced neurobehavioral disease pathogenesis. Curr Opin Microbiol 2001; 4: 467-475.

Miranda HC, Nunes SO, Calvo ES, Suzart S, Itano EN, Watanabe MA. Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients. J Affect Disord 2006; 90: 43-47.

Nakamura Y, Takahashi H, Shoya Y, Nakaya T, Watanabe M, Tomonaga K, et al. Isolation of Borna disease virus from human brain tissue. J Virol 2000; 74: 4601-4611.

Koster-Patzlaff C, Hosseini SM, Reuss B. Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro. Brain Res 2007; 1184: 316-332.

Kishi M, Arimura Y, Ikuta K, Shoya Y, Lai PK, Kakinuma M. Sequence variability of Borna disease virus open reading frame II found in human peripheral blood mononuclear cells. J Virol 1996; 70: 635-640.

Puerto F, Zavala J, Rosado A, Gamboa J. Serological survey of Borna disease virus in schizophrenec patients from Yucatán, México. Rev Biomed 2004; 15: 141-147.

Zhang L, Xu MM, Zeng L, Liu S, Liu X, Wang X, et al. Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. Eur J Clin Microbiol Infect Dis 2014; 33: 621-627.

Mazaheri-Tehrani E, Maghsoudi N, Shams J, Soori H, Atashi H, Motamedi F, et al. Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. Virol J 2014; 11: 161.

Iwata Y, Takahashi K, Peng X, Fukuda K, Ohno K, Ogawa T, et al. Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. J Virol 1998; 72: 10044-10049.

Selten JP, van Vliet K, Pleyte W, Herzog S, Hoek HW, van Loon AM. Borna disease virus and schizophrenia in Surinamese immigrants to the Netherlands. Med Microbiol Immunol 2000; 189: 55-57.

Na KS, Tae SH, Song JW, Kim YK. Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients. Psychiatry Investig 2009; 6: 306-312.

Bahmani MK, Nowrouzian I, Nakaya T, Nakamura Y, Hagiwara K, Takahashi H, et al. Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. Virus Res 1996; 45: 1-13.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.