Assessing cognition, depression and anxiety in hospitalized patients during pre and post-Bone Marrow Transplantation
Objective: Bone Marrow Transplantation is considered one of the main procedures used in the treatment of both malignant and non-malignant diseases. Psychological factors after Bone Marrow Transplantation have an important role in the survival of the patients undergoing this procedure.
Method: In the present study, some parameters including depression, anxiety and cognition were assessed during both pre and post-transplantation in patients undergoing Bone Marrow Transplantation. The evaluations were performed by utilizing several questionnaires including Hospital Anxiety and Depression Scale and Wechsler Memory Scale within 72 hours after hospitalization (pre-transplantation) and one month after transplantation (post-transplantation). All patients received intensive chemotherapy during the first 72 hours after hospitalization. Paired t test was used to compare pre and post values. SPSS (version 18) was used to analysis the data. The significance level was defined as p < 0.05.
Results: Twenty one patients who were not receiving any antianxiety agents at least for two weeks prior to and during this study were included. It was noted that anxiety was significantly less at post-transplantation compared to its pre-transplantation level (P = 0.008). However, no significant difference was found between pre and post-transplantation depression. Memory function was significantly improved at post-transplantation compared to pre-transplantation (P = 0.001).
Conclusion: The authors suggest that the improvement of anxiety and memory status of the patients one month after the bone marrow transplantation is expected even in the absence of consumption of any antianxiety agents. However, antidepressants may be needed to help those patients who undergo bone marrow transplantation.
Chao NJ, Tierney DK, Bloom JR, Long GD, Barr TA, Stallbaum BA, et al. Dynamic assessment of quality of life after autologous bone marrow transplantation. Blood J 1992; 80: 825-830.
Mosher CE, Redd WH, Rini CM, Burkhalter JE, DuHamel KN. Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: a review of the literature. Psycho - oncology 2009; 18: 113-27.
Baker F, Zabora J, Polland A, Wingard J. Reintegration after Bone Marrow Transplantation. Cancer Practice 1999; 7: 190–197.
Maheri Azar R, Nikoogoftar M, Salehi S, Zohoor AR. Anxiety and depression in pre – and – post Hematopoietic Stem Cell Transplant in SCT center, Shariaty hospital, Tehran, Iran. IJHOSC 2010; 4: 17-21.
Akaho R, Sasaki T, Mori S, Akiyama H, Yoshino M, Hagiya K, et al. Psychological factors and survival after bone marrow transplantation in patients with leukemia. Psychiatry Clin Neurosci 2003; 57: 91–96.
Booth-Jones M, Jacobsen PB, Ransom S, Soety E. Characteristics and correlates of cognitive functioning following bone marrow transplantation. Bone Marrow Transplant 2005; 36: 695–702.
Jacobs SR., Validation of the functional assessment of cancer therapy cognitive scale with bone marrow transplant patients. Graduate School Theses and Dissertations 2004; 1092.
Syrjala KL, Dikmen S, Langer SL, Roth-Roemer S, Abrams JR. Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant. Blood. 2004; 104: 3386-3392.
Phipps S, Dunavant M, Srivastava KD., Bowman L, Mulhern KR. Cognitive and Academic Functioning in Survivors of Pediatric Bone Marrow Transplantation. J Clin Oncol 2000; 18: 1004-1011.
Khan AG, Irfan M, Shamsi T.S, Hussain M. Psychiatric disorders in Bone Marrow Transplantation patients. J Coll Physicians Surg Pak 2007; 17: 98-100.
Kaviani H, Seyfourian H, Sharifi V, Ebrahimkhani N. [Reliability and validity of Anxiety and Depression Hospital Scales (HADS): Iranian patients with anxiety and depression disorders (Persian)]. Tehran University Medical Journal 2009; 67: 379-385.
Wechsler Memory Scale. Translators to Farsi: Nasri s., Bagheri Yazdi S. Unser supervision of Barahani MN. Available by Tehran Psychiatry Institution 1991.(unpublished record)
en.wikipedia [home page on Internet]. [Last modified on 2011 June 16 at 12:06; cited 2012 Sep 12]. Available from: http://en.wikipedia.org/wiki/Wechsler_Memory_Scale.
Chiodi S, Spinelli S, Ravera G, Petti AR, Van Lint MT, Lamparelli T, et al. Quality of life in 244 recipients of allogeneic bone marrow transplantation. Br Journal Haematol 2000; 110: 614–619.
Fife BL, Huster GA, Cornetta KG, Kennedy VN, Akard LP, Broun ER. Longitudinal study of adaptation to the stress of bone marrow transplantation. J Clin Oncol 2000; 18: 1539-1549.
Trask PC, Paterson A, Riba M, Brines B, Griffith K, Parker P, et al. Assessment of psychological distress in prospective bone marrow transplant. Bone Marrow Transplantation 2002; 29: 917-925.
Syrjala KL, Langer SL, Abrams JR, Storer B, Sanders JE, Flowers ME, et al. Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 2004; 291: 2335-2343.
Grulke N, Larbig W, Kächele H, Bailer H. Pre-transplant depression as risk factor for survival of patients undergoing allogeneic haematopoietic stem cell transplantation. Psycho-oncology 2008; 17: 480-487.
Harder H, Cornelissen JJ, Van Gool AR, Duivenvoorden HJ, Eijkenboom WM, van den Bent MJ. Cognitive Functioning and Quality of Life in Long-Term Adult Survivors of Bone Marrow Transplantation. Cancer 2002; 95: 183–92.
Meyers CA, Weitzner M, Byrne K, Valentine A, Champlin RE, Przepiorka D. Evaluation of the neurobehavioral functioning of patients before, during, and after bone marrow transplantation. J Clin Oncol 1994; 12: 820-6
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.