Non-Recurrence of Carbamazepine Induced Vitiligo after Rechallenge with Carbamazepine

  • Masoomeh Saeedloo Mental Health Research Center and Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Seyed Vahid Shariat Mail Mental Health Research Center and Department of Psychiatry, Tehran Institute of Psychiatry-Faculty of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran
bipolar disorder, carbamazepine, vitiligo


Objective: Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine .
Methods: The case was a patient with Bipolar I disorder whose medications were changed from valproate to carbamazepine and who developed vitiligo after a short while. We followed the case for about four years when he was rechallenged with carbamazepine.
When depigmentation occurred, we immediately discontinued carbamazepine after which the depigmented areas improved gradually. About three years later, he received carbamazepine again, but depigmentation did not recur.
Carbamazepine-induced vitiligo is not an absolute contraindication for the prescription of carbamazepine if other choices fail to respond or are not tolerated. The case has implications for the mechanism of medication induced vitiligo.


Taieb A, Picardo M. Clinical Practice. Vitiligo. N Engl J Med 2009; 360: 160-169.

Namazi MR. Phenytoin as a Novel Anti-Vitiligo Weapon. J Autoimmune Dis 2005; 2: 11.

Curzytek K, Pietowska J, Spiewak R. Drug-induced vitiligo: A meta-analysis of reported cases. J Physiol Pharmacol. 2007; 58 (Suppl 4: First International Conference "Medical Biology and Human Life"):66.

Yazidi A, Belagnaoui F Z, Benzekri L, K. S, Hassam B. Vitiligo au décours d'une érythrodermie induite par la carbamazépine (Tégrétol®). Les Nouvelles dermatologiques 1999; 18: 514-515.

Gitlin M, Frye MA. Maintenance Therapies in Bipolar Disorders. Bipolar disorders 2012; 14 Suppl 2: 51-65.

Ceron-Litvoc D, Soares BG, Geddes J, Litvoc J, de Lima MS. Comparison of Carbamazepine and Lithium in Treatment of Bipolar Disorder: A Systematic Review of Randomized Controlled Trials. Hum Psychopharmacol 2009; 24: 19-28.

Sadock BJ, Sadock VA, Ruiz P, Kaplan HI. Kaplan and Sadock's Comprehensive Textbook of Psychiatry. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2009.

How to Cite
Saeedloo M, Shariat SV. Non-Recurrence of Carbamazepine Induced Vitiligo after Rechallenge with Carbamazepine. Iran J Psychiatry. 8(4):201-3.