Editorial

Inflammatory Markers: Promising Tools for Diagnosis of Eating Disorders and Response to Treatment

Abstract

Eating disorders are important psychiatric conditions with serious implications for physical and mental health. These disorders may be seen in all age groups ages but are more common in adolescents and young adults. Anorexia nervosa, bulimia nervosa, and binge-eating disorder are the main eating disorders. These disorders are triggered by acute stress regarding distorted body image and identified by persistent changes in eating behaviors. Each eating disorder involves different clinical features, but they all share some common risk factors, including genetic predisposition, environmental factors, and psychological triggers. Inflammation is a core mechanism that underlies the pathophysiology of eating disorders. This editorial essay will discuss the evidence linking inflammatory markers to eating disorders' etiology, diagnosis, and treatment.

1. Mehler PS, Koutsavlis A. Anorexia Nervosa, Albumin, and Inflammation. Am J Med. 2021;134(6):e401.
2. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204-18.
3. Breithaupt L, Holsen LM, Ji C, Hu J, Petterway F, Rosa-Caldwell M, et al. Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation Associated Biomarkers Using Multiplex Profiling in Anorexia Nervosa and Atypical Anorexia Nervosa. bioRxiv. 2023:2023.06. 30.547289.
4. Barakat S, McLean SA, Bryant E, Le A, Marks P, Touyz S, et al. Risk factors for eating disorders: findings from a rapid review. J Eat Disord. 2023;11(1):8.
5. Pourhassan M, Sieske L, Janssen G, Babel N, Westhoff TH, Wirth R. The impact of acute changes of inflammation on appetite and food intake among older hospitalised patients. Br J Nutr. 2020;124(10):1069-75.
6. Maunder K, Molloy E, Jenkins E, Hayden J, Adamis D, McNicholas F. Anorexia Nervosa in vivo cytokine production: a systematic review. Psychoneuroendocrinology. 2023;158:106390.
7. Dalton B, Campbell IC, Chung R, Breen G, Schmidt U, Himmerich H. Inflammatory Markers in Anorexia Nervosa: An Exploratory Study. Nutrients. 2018;10(11).
8. Baenas I, Etxandi M, Fernández-Aranda F. Medical complications in anorexia and bulimia nervosa. Med Clin (Barc). 2023.
9. Stamu-O'Brien C, Shivakumar S, Messas T, Kroumpouzos G. Through the looking glass: Skin signs that help diagnose eating disorders. Clin Dermatol. 2023;41(1):67-74.
10. Sun R, Sugiyama M, Wang S, Kuno M, Sasaki T, Hirose T, et al. Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating. Nutrients. 2022;14(18).
Files
IssueVol 19 No 2 (2024) QRcode
SectionEditorial
DOI https://doi.org/10.18502/ijps.v19i2.15101
Keywords
inflammation eating disorders IL-6 CRP
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Mostafavi S-A. Inflammatory Markers: Promising Tools for Diagnosis of Eating Disorders and Response to Treatment. Iran J Psychiatry. 2024;19(2):155-157.