Evaluation of Cerebral Cortex Function in Clients with Bipolar Mood Disorder I (BMD I) Compared With BMD II Using QEEG Analysis

  • Ali Khaleghi Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Ali Sheikhani Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • MohammadReza Mohammadi Psychiatry and Psychology Research Center, Roozbeh hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Ali Moti-Nasrabadi Biomedical Engineering Department, Shahed University, Tehran, Iran
Bipolar Mood Disorder I, Bipolar Mood Disorder II, Quantitative Electroencephalography, Entropy


Objective: Early diagnosis of type I and type II bipolar mood disorder is very challenging particularly in adolescence. Hence, we aimed to investigate the cerebral cortex function in these patients, using quantitative electroencephalography analysis to obtain significant differences between them.
Methods: Thirty- eight adolescents (18 patients with bipolar disorder I and 20 with BMD II) participated in this study. We recorded the electroencephalogram signals based on 10-20 international system by 21 electrodes in eyes open and eyes closed condition resting conditions. Forty seconds segments were selected from each recorded signals with minimal noise and artifacts. Periodogram Welch was used to estimate power spectrum density from each segment. Analysis was performed in five frequency bands (delta, theta, alpha, beta and gamma), and we assessed power, mean, entropy, variance and skewness of the spectrums, as well as mean of the thresholded spectrum and thresholded spectrogram. We only used focal montage for comparison. Eventually, data were analyzed by independent Mann-Whitney test and independent t test.
Results: We observed significant differences in some brain regions and in all frequency bands. There were significant differences in prefrontal lobe, central lobe, left parietal lobe, occipital lobe and temporal lobe between BMD I and BMD II (P < 0.05). In patients with BMD I, spectral entropy was compared to patients with BMD II. The most significant difference was observed in the gamma frequency band. Also, the power and entropy of delta frequency band was larger in the left parietal lobe in the BMD I patients compared to BMD II patients (P < 0.05). In the temporal lobe, significant differences were observed in the spectrum distribution of beta and gamma frequency bands (P < 0.05).
Conclusion: The QEEG and entropy measure are simple and available tools to help detect cerebral cortex deficits and distinguish BMD I from BMD II.


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How to Cite
Khaleghi A, Sheikhani A, Mohammadi M, Moti-Nasrabadi A. Evaluation of Cerebral Cortex Function in Clients with Bipolar Mood Disorder I (BMD I) Compared With BMD II Using QEEG Analysis. Iran J Psychiatry. 10(2):93-99.
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