Escitalopram in Preschool-Age Children Diagnosed with ‎Obsessive ‎Compulsive‏ ‏Disorder: A Case Report‎

  • Kemal Utku Yazici Mail Department of Child and Adolescent Psychiatry, Firat University Medical Faculty, Elazig, Turkey
  • Ipek Percinel Osmaniye State Hospital, Department of Child and Adolescent Psychiatry, Osmaniye, Turkey
Preschool Child, Obsessive-Compulsive ‎Disorder, Escitalopram


When a literature review on pediatric obsessive-compulsive disorder (OCD) is ‎performed, it is observed that there is a dearth of research on preschool period OCD ‎cases. Although cognitive behavioral therapy is recommended as the first line of ‎treatment in preschool OCD cases when patients do not show adequate response to ‎CBT, psychopharmacological treatment offers an alternative. The first line used in ‎psychopharmacological treatment is selective serotonin reuptake inhibitors (SSRI’s). ‎However, no SSRI’s (or any other drug group) have been approved by the FDA for this ‎age group. Moreover, studies related to psychopharmacology in preschool OCD are very ‎limited in the literature, consisting mostly of case reports related to sertraline and ‎fluoxetine. In those studies, it is reported that sertraline and fluoxetine are effective in ‎preschool OCD and generally well-tolerated. In this paper, we discussed the treatment ‎and six-month follow-up period of a 3.5 year-old (42 months) female diagnosed with ‎OCD and for whom escitalopram was used. In the literature, there is a retrospective case ‎series related to this subject consisting of eleven cases, where improvement in symptoms ‎is reported with escitalopram treatment in the five of six cases diagnosed with OCD. As ‎far as we could find in literature, our paper is the second report on this subject. Our case ‎also included the youngest patient to receive escitalopram for preschool period OCD ‎and report its benefits.‎


Jenike MA. Clinical practice. Obsessive-compulsive disorder. N Engl J Med 2004; 35: 259-265.

Heyman I, Mataix–Cols D, Fineberg NA. Obsessive-compulsive disorder. BMJ 2006; 333: 424-429.

Gleason MM, Egger HL, Emslie GJ, Greenhill LL, Kowatch RA, Lieberman AF, et al. Psychopharmacological treatment for very young children: contexts and guidelines. J Am Acad Child Adolesc Psychiatry 2007; 46: 1532-1572.

Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, et al. Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 1997; 36: 844-852.

Oner O, Oner P. Psychopharmacology of pediatric obsessive-compulsive disorder: three case reports. J Psychopharmacol 2008; 22: 809-811.

Coskun M, Zoroglu S. Efficacy and safety of fluoxetine in preschool children with obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 2009; 19: 297- 300.

Coskun M, Ozturk M, Zoroglu S. Escitalopram treatment in preschool children with anxiety disorders: a case series. Bulletin of Clinical Psychopharmacology 2012; 22: 262-267.

Ercan ES, Kandulu R, Akyol Ardic U. Preschool children with obsessive- compulsive disorder and fluoxetine treatment. Eur Child Adolesc Psychiatry 2012; 21: 169-172.

Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, et al. Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive- compulsive disorder. Am J Psychiatry 2003; 160: 1919-1928.

Zuckerman ML, Vaughan BL, Whitney J, Dodds A, Yakhkind A, MacMillan C, et al. Tolerability of selective serotonin reuptake inhibitors in thirty-nine children under age seven: a retrospective chart review. J Child Adolesc Psychopharmacol 2007; 17: 165-174.

Taylor S. Early versus late onset obsessive-compulsive disorder: evidence for distinct subtypes. Clin Psychol Rev 2011; 31: 1083-1100.

Pallanti S, Quercioli L. Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 400-412.

How to Cite
Utku Yazici K, Percinel I. Escitalopram in Preschool-Age Children Diagnosed with ‎Obsessive ‎Compulsive‏ ‏Disorder: A Case Report‎. Iran J Psychiatry. 11(1):64-66.
Case Report(s)