Quantitative electroencephalogram (QEEG) Spectrum Analysis of Patients with Schizoaffective Disorder Compared to Normal Subjects.
AbstractObjective: The aim of this study was to achieve a better understanding of schizoaffective disorder. Therefore, we obtained electroencephalogram (EEG) signals from patients with schizoaffective disorder and analyzed them in comparison to normal subjects.
Method: Forty patients with schizoaffective disorder and 40 normal subjects were selected randomly and their electroencephalogram signals were recorded based on 10-20 international system by 23 electrodes in open- and closed-eyes while they were sitting on a chair comfortably. After pre-processing for noise removal and artifact reduction, we took 60- second segments from each recorded signals. Then, the absolute and relative powers of these segments were evaluated in all channels and in 4 frequency bands (i.e., delta, theta, alpha and beta waves). Finally, Data were analyzed by independent t-test using SPSS software.
Results: A significant decrease in relative power in the alpha band, a significant decrease in power spectra in the alpha band and a significant increase in power spectra in the beta band were found in patients compared to normal subjects (P < 0.05). The predominant wave in the centro-parietal region was the beta wave in patients, but it was the alpha band in normal subjects (P = 0.048). Also, the predominant wave of the occipital region in patients was the delta wave, while it was the alpha wave in normal subjects (P = 0.038).
Conclusion: Considering the findings, particularly based on the significant decrease of the alpha waves in schizoaffective patients, it can be concluded that schizoaffective disorder can be seen in schizophrenia spectrum.
Sadock BJ, Kaplan HI , Sadock VA. Kaplan & Sadock's synopsis of psychiatry: behavioral sciences/clinical psychiatry. City: Lippincott Williams & Wilkins; 2007.
Association AP. Diagnostic And Statistical Manual Of Mental Disorders DSM-IV-TR Fourth Edition (Text Revision) Author: American Psychiatr. 2000.
Schellenberg R , Schwarz A. EEG-and EP-mapping—Possible indicators for disturbed information processing in schizophrenia? Progress in Neuro-Psychopharmacology and Biological Psychiatry 1993; 17: 595-607.
Locatelli M, Angeli AD, Leone E, Grassi B , Scarone S. Factor analysis and computerized EEG: preliminary data on schizophrenic patients. International journal of neuroscience 1993; 72: 265-270.
Michael Kahn E, Weiner RD, Coppola R, Kudler HS , Schultz K. Spectral and topographic analysis of EEG in schizophrenic patients. Biological psychiatry 1993; 33: 284-290.
Clementz BA, Sponheim SR, Iacono WG , Beiser M. Resting EEG in first‐episode schizophrenia patients, bipolar psychosis patients, and their first‐degree relatives. Psychophysiology 1994; 31: 486-494.
Koles Z, Lind J , Flor-Henry P. Spatial patterns in the background EEG underlying mental disease in man. Electroencephalography and clinical neurophysiology 1994; 91: 319-328.
Winterer G, Ziller M, Dorn H, Frick K, Mulert C, Wuebben Y, et al. Frontal dysfunction in schizophrenia–a new electrophysiological classifier for research and clinical applications. European archives of psychiatry and clinical neuroscience 2000; 250: 207-214.
Ramos J, Cerdán LF, Guevara MA, Amezcua C , Sanz A. Abnormal EEG patterns in treatment-resistant schizophrenic patients. International journal of neuroscience 2001; 109: 47-59.
10. Knott V, Labelle A, Jones B , Mahoney C. Quantitative EEG in schizophrenia and in response to acute and chronic clozapine treatment. Schizophrenia research 2001; 50: 41-53.
Kirino E. Correlation between P300 and EEG rhythm in schizophrenia. Clinical EEG and neuroscience 2004; 35: 137-146.
Harris A, Melkonian D, Williams L , Gordon E. Dynamic spectral analysis findings in first episode and chronic schizophrenia. International journal of neuroscience 2006; 116: 223-246.
Zaytseva Y, Garakh Z, Kapranova A, Gurovich IY , Strelets VB. 1349 – Evidence of neurophysiological distinction between schizophrenia and schizoaffective disorder. European Psychiatry 2013; 28, Supplement 1: 1.
Boutros NN, Arfken C, Galderisi S, Warrick J, Pratt G , Iacono W. The status of spectral EEG abnormality as a diagnostic test for schizophrenia. Schizophrenia research 2008; 99: 225-237.