Iranian Journal of Psychiatry 2017. 12(4):262-268.

Catechol-O-Methyltransferase (COMT) Gene (Val158Met) and Brain-Derived Neurotropic Factor (BDNF) (Val66Met) Genes Polymorphism in Schizophrenia: A Case-Control Study
ramin saravani, Hamid Reza Galavi, Marzieh Lotfian Sargazi


Objective: The effects of human brain-derived neurotropic factor (BDNF) Val66Met (G>A) and the human Catechol-O-methylTransferase (COMT) Val158Met (G>A) polymorphisms on Schizophrenia (SCZ) risk were evaluated.

Methods: This case control study included 92 SCZ patients and 92 healthy controls (HCs). Genotyping of both variants were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR).

Results: The findings showed that BDNF Val66Met (G>A) variant increased the risk of SCZ (OR=2.008 95%CI=1.008-4.00, P=0.047, GA vs. GG, OR=3.876 95%CI=1.001-14.925, P=0.049. AA vs. GG, OR=2.272. 95%CI=1.204-4.347, P=0.011, GA+AA vs. GG, OR=2.22 95%CI=1.29-3.82. P=0.005, A vs. G). COMT Val158Met (G>A) polymorphism was not associated with the risk/protective of SCZ.

Conclusion: The results proposed that BDNF Val66Met (G>A) polymorphism may increase the risk of SCZ development and did not support an association between COMT Val158Met (G>A) variant and risk/protective of SCZ. Further studies and different ethnicities are recommended to confirm the findings.


BDNF; COMT; Schizophrenia; Single Nucleotide Polymorphism

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