2023 CiteScore: 4
pISSN: 1735-4587
eISSN: 2008-2215
Editor-in-Chief:
Mohammad Reza Mohammadi, MD.
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE).
Vol 2 No 2 (2007)
Objective: Exposure to traumatic stressors lead to activation of arousal responses mediated by serotonergic and noradrenergic systems and it may cause a change in numerous neurotransmitters and neuroendocrine systems. There is ample experimental and clinical evidence to suggest that Ginkgo biloba extract is neuroprotective and has antioxidant properties and can restore stress-induced elevation in brain levels of catecholamines, 5-HT and plasma corticosterone to normal level.
Method: In a 12-week, double-blind, placebo-controlled study, the efficacy and safety of adding-on a fixed-dose (200mg) of Ginkgo TD to the previous treatment regime of adults with PTSD were examined. Subjects were forty male and female outpatients from a public-owned psychiatric clinic who met criteria for PTSD seven month after a 6.3 Richter earthquake in Bam city on December 26, 2003. The changes in five symptom domains including posttraumatic stress, anxiety and affective symptoms, general health and subjective stress after trauma were ssessed at weeks 0, 12 and 16 to examine effectiveness of the added-on Ginkgo TD and stability of its effects.
Results: Ginkgo TD was associated with a significantly greater improvement than placebo in PTSD patients as measured by five symptom domain scales including: GHQ-28; Watson PTSD Scale; HAM-D; HAM-A and IES (p= 0.02, 0.01, 0.001, 0.01, 0.02 respectively) Four weeks after the discontinuation of intervention, no significant difference was determined between the two groups in the five outcome measures (p= 0.005, 0.01, 0.004, 0.005, 0.01 respectively). No significant difference was observed between the two groups in terms of side effects.
Conclusions: We found Ginkgo TD to be superior to placebo as an adding-on in the treatment of PTSD. Although we did not examine the comparative efficacy of Ginkgo TD on the three main elements of PTSD, beneficial effects both on specific PTSD symptomatology and general conditions including anxiety, depression, general health and perceived stress were indicated.
Objective: The aim of the present study is to examine the factors related aggression in Iranian and Indian school children.
Method: Attachment security (dependency, availability, and total) considered as the variable. The KSS questionnaire was administrated students in the 5th grade; 300 were Iranian and 300 were Indian consisted of 150 boys and 150 girls).
Results: Attachment security demonstrated significant negative correlations with aggression in the boys, girls and the total Iranian sample. The dependency on mothers was the only case with insignificant correlation.In the Indian sample, attachment security was also found to be significantly negatively correlated with aggression. The only exception was the correlation between mother's availability and aggression in girls, which was not significant
Conclusion: It is important that parents treat their children in a tender, manner so that a secure attachment develop between them.
Objective: Although there are some reports of reduction of obsessive-compulsive symptoms in manic episodes or its exacerbation during depressive episodes, this relationship has not been proved.
Method: Clinical observations of six cases with co-morbidity of bipolar-I-disorder and obsessive-compulsive disorder or symptoms.
Results: The cases presented here show heterogeneity and variety of the relationships between the obsessions and bipolar-I-disorder.Limitations: Low sample size and non-random sampling.
Conclusions: This variety of clinical presentations may indicate the presence of different clinical groups that their validity should be assessed through more systematized studies.
2023 CiteScore: 4
pISSN: 1735-4587
eISSN: 2008-2215
Editor-in-Chief:
Mohammad Reza Mohammadi, MD.
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE).
All the work in this journal are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |